Authors : Talaat I. EL-Sayed, Dina Atef, Mahmoud Amer, Ahmed Mahdy and Gamal Enan
Abstract: The prevalence percentage of vaginal candidiasis appeared to be 49% within Egyptian pregnant women suffering from vaginal pain and vaginal discharge. The 61.2% of the 49 patients were multigravidae and almost in the age range 20-30 years. Based on phenotypic and biochemical characteristics, the infective 49 isolates causing vaginal candidiasis could be classified and identified to C. albicans group (32 isolates), C. tropicalis group (12 isolates) and C. dubliniensis group (5 isolates). Three strains of them viz. C. albicans ZUH1 , C. trobicalis ZUH13 and C. dubliniensis ZUH9 were resistant to 6 antifungal agents used and the antifungal resistance ability in each of them was genetically encoded and linked to one plasmid in each of them, almost in the range 600-800 bp. Of many natural agents used as antifungals, aqueous extracts of alum and clove inhibited vigorously the antifungal resistant strains: C. albicans ZUH1 , C. trobicalis ZUH13 and C. dubliniensis ZUH9 ; no colony forming units were detected onto Sabouraud agar after 5 days of incubation from samples 9 treated with either alum or clove extracts.
Talaat I. EL-Sayed, Dina Atef, Mahmoud Amer, Ahmed Mahdy and Gamal Enan, 2015. Molecular Characterization and Inhibition by Natural Agents of Multidrug Resistant Candida Strains Causing Vaginal Candidiasis. Research Journal of Medical Sciences, 9: 1-7.