Authors : Vladimir F. Kulikovsky, Alexander M. Mishustin, Andrei L. Iarosh, Alexander V. Soloshenko, Alexander A. Karpachev, Arman A. Oganesyan and Yurii Y. Vlasuk
Abstract: The study analyzed the results of surgical treatment among 185 patients with postoperative ventral hernias. All patients were divided into two matched groups. The first group consisted of 128 patients who underwent the plastic operation of abdominal wall defect with the use of mesh prosthesis “Esfil light” (“linteks”, Russia). The second group included 57 patients with the plastic operation of abdominal wall defect using the mesh endoprosthesis “Esfil light” and TachoComb® was used additionally (RF patent number 2391051 “Ventral hernia treatment method”). It was found that use of the drug TachoComb® during the implantation of the mesh prosthesis “Esfil light” allowed to reduce significantly the severity of the inflammatory response in the area of operation which was characterized by lower level of pro-inflammatory cytokines TNFα, IL 1β, IL 6 and a higher level of anti-inflammatory cytokines IL 10 and IL 1RA in the wound fluid at all stages of the study.
Vladimir F. Kulikovsky, Alexander M. Mishustin, Andrei L. Iarosh, Alexander V. Soloshenko, Alexander A. Karpachev, Arman A. Oganesyan and Yurii Y. Vlasuk, 2015. Local Inflammatory Reaction at Soft Tissue Defects Reconstruction. Research Journal of Medical Sciences, 9: 171-174.