Authors : Hashem Kazerani, Laila Valizadeh, Nader Asgari, Behzad hajimoradi, Alireza Rai, Reza Hedari Moghadam, Sanam Golshani and Rahim Nanvaie
Abstract: Hyperandrogenism which is characterized by excessive production of androgen by ovaries or adrenal glands, is regarded as one of the probable risk factors for cardiovascular diseases. This study was conducted to determine the association between coronary artery disease and hyperandrogenism in women. In this cross-sectional study, the research population was women under 60 who were admitted to Imam Ali Hospital of Kermanshah for angiography. The sample size included 116 people who were selected through available sampling. Coronary artery disease risk factors were evaluated using interview technique and taking patient’ medical history. Blood sample was taken and tested to measure testosterone and blood glucose and lipids variables. Then, all patients were undergone coronary angiography. Data were analyzed using SPSS-16 software and Chi-square, t-test and regression statistical tests.Out of 116 patients under study, 58 people had abnormal angiography and 58 patients normal one. Among the studied heart risk factors, history of diabetes, family history of CAD and the history of previous MI in abnormal angiography group were significantly greater than normal group (p<0.05). Considering the hyperandrogenism symptoms, hirsutism and androgenetic alopecia in abnormal angiography group were significantly greater than normal group (p<0.05). In addition, the regression test results also indicated the presence of a significant relationship between BMI, history of previous MI and the presence of hirsutism symptom with the incidence of positive findings in angiography (p<0.05). The results of this study showed that hyperandrogenism symptoms could be considered as one of the risk factors associated with cardiovascular diseases.
Hashem Kazerani, Laila Valizadeh, Nader Asgari, Behzad hajimoradi, Alireza Rai, Reza Hedari Moghadam, Sanam Golshani and Rahim Nanvaie, 2016. Understanding the Association between Coronary Artery Disease and Hyperandrogenism in Women. Research Journal of Medical Sciences, 10: 694-700.