Abstract: The pharmacokinetics of tylosin after intramuscular administration at a dose of 1g kg-1 body weight was studied in eleven healthy desert sheep. A peak level of tylosin Cmax of 198±0.95 µg mL 1 was achieved after tmax of 0,9±0.13 h and the mean distribution half-life (t1/2 ) was 2±0.3 h and the apparent elimination half-life (t1/2 ) was 72.2±9.3 h. The volume of distribution (Vd) was found to be 53.299±3.907 L. The area under the curve (AUC°240) of tylosin was calculated as being 1947.8±177.8 µg mL 1 and the Area Under Maximum Concentration Curve (AUMC) was 74285.4±5420.75 µg/mL/h2. The total clearance (cl ) was 511.7±207 µl h 1 and the mean resident time was 30±9.83 h.
A.I. Sana Shaddad , A.A. Samia Hassan , I.B. ElTayeb , M.A. Omer , A.O.M. Nour , M.H. Al-Nazawi and A.M. Homeida , 2007. Pharmacokinetics of Tylosin in Desert Sheep after Intramuscular Injection. Research Journal of Pharmacology, 1: 19-22.