Authors : 1Irfan Tasoglu , 1Yildirim Imren , 2Mehmet Gungor Kaya , 1Dilek Erer , 1Erkan Iriz and 1Mehmet Emin Ozdogan
Abstract: Cyclosporine-A(CsA) can cause a wide range of adverse effect on both the Central Nervous System(CNS) and Peripheral Nervous System(PNS). Side effects of CsA on CNS have been reported to occur in up to 42% of patients. However the majority of these reports has been obtained from studies in bone marrow and liver transplantation recipients. There are few reports about CsA induced neurotoxicity after heart transplantation. A 65-year-old female patient who underwent heart transplantation for cardiomyopathy, received azathioprine, prednisolone, CsA in the postoperative period. She was administered CsA at 3 mg kg day and blood CsA (Co) levels ranged between 250-350 ng mL 1. CsA induced neurotoxicity occured at postoperative 6th month. Neurotoxicity of CsA generally occurs with intravenous administration of high levels , in the presence of a predisposing factor and early treatment period which is reversible. In our patient CsA induced neurotoxicity occured with normal levels of CsA, oral CsA treatment and in late treatment period. Although all the symptoms due to neurotoxicity were reversible, ptosis remained as an irreversible sequela. For this reason clinicians must be aware of the neurotoxic side effects from the begining to the end of the therapy.
1Irfan Tasoglu , 1Yildirim Imren , 2Mehmet Gungor Kaya , 1Dilek Erer , 1Erkan Iriz and 1Mehmet Emin Ozdogan , 2005. Cyclosporin A Induced Neurotoxicty After Heart Transplantation. The Cardiology, 1: 169-171.