Research Journal of Pharmacology

Year: 2012
Volume: 6
Issue: 2
Page No. 30 - 34

Protective Effect of the Leaf Extracts of Combretum racemosum P. Beauv (Combretaceae) on Cyclophospahamide Induced Pancytopaenia and Liver Injury in Male Rats

Authors : C.N. Okwuosa, P.U.O. Achukwu , N.C. Azubike and A.I.E. Abah

References

Aschan, J., S. Carlens, H. Hagglund, S. Klaesson, J. Mattson and M. Remberger, 1999. Improved survival after bone marrow transplantation for early leukemia using busultan-cyclophosphamide and individualized prophylaxis against graft-versus-host disease: A long-term follow-up. Clin. Transplant., 13: 512-519.

De Smet, P.A.G.M., 2002. Herbal remedies. N. Engl. J. Med., 347: 2046-2056.
CrossRef  |  Direct Link  |  

Defeudis F.V., V. Papadopoulos and K. Drieu, 2003. Gingko biloba extracts and cancer: A research area in infancy. Fundam. Clin. Pharma., 17: 405-417.
PubMed  |  

Groopman, J.E. and L.M. Itri, 1999. Chemotherapy-induced anemia in adults: Incidence and treatment. J. Natl. Cancer Inst., 91: 1616-1634.
PubMed  |  

Halliwell, B., 1991. Drug antioxidant effects. A basis for drug selection. Drugs, 42: 569-605.
CrossRef  |  PubMed  |  Direct Link  |  

Huang, Z., M.K. Raychowdhury and D.J. Waxman, 2000. Impact of liver P450 reductase suppression on cyclophosphamide activation, pharmacokinetics and antitumoral activity in cytochrome P450-based cancer gene therapy model. Cancer Gene Ther., 7: 1034-1042.

Kaya, H., B. Oral, F. Ozguner, V. Tahan, Y. Babar and N. Delibas, 1999. The effect of melatonin application on lipid peroxidation during cyclophosphamide therapy in female rats. Zentralbl Gynakol, 121: 499-502.
PubMed  |  

Kumar, G., G.S. Banu, V. Kannan and M.R. Pandian, 2005. Antihepatotoxic effect of β-carotene on paracetamol induced hepatic damage in rats. Ind. J. Exp. Biol., 43: 351-355.
PubMed  |  

Lear, L., R.L. Nation and I. Stupans, 1992. Effects of cyclophosphamide and adriamycin on rat hepatic microsomal glucuronidation and lipid peroxidation. Biochem. Pharmacol., 44: 747-753.
CrossRef  |  PubMed  |  Direct Link  |  

Lorke, D., 1983. A new approach to practical acute toxicity testing. Arch. Toxicol., 54: 275-287.
CrossRef  |  PubMed  |  Direct Link  |  

Mathew, S. and G. Kuttan, 1997. Antioxidant activity of Tinospora cordifolia and its usefulness in the amelioration of cyclophosphamide induced toxicity. J. Exp. Clin. Cancer Res., 16: 407-411.
PubMed  |  

Nichols, C.R., E.P. Fox, B.J. Roth, S.D. Williams, P.J. Loehrer and L.H. Einhorn, 1994. Incidence of neutropenic fever in patients treated with standard-dose combination chemotherapy for small-c0ell lung cancer and the cost impart of treatment with granulocyte colony-stimulating factor. J. Clin. Oncol., 12: 1245-1250.
PubMed  |  

Okochi, V.I., J. Okpuzor and L.A. Alli, 2003. Comparison of an African herbal formula with commercially available haematinics. Afr. J. Biotechnol., 2: 237-240.
Direct Link  |  

Okwuosa, C.N., P.C. Unekwe, E. Nwobodo and K. Chilaka, 2006. The anti-ulcer activities of leaf extract of Combretum racemosum (Combretaceae). J. Biomed. Inves., 4: 8-14.

Patel, J.M. and E.R. Block, 1985. Cyclophosphamide-induced depression of the antioxidant defense mechanisms of the lungs. Exp. Lung Res., 8: 153-165.
CrossRef  |  

Premkumar, K., A. Pachiappan, S.K. Abraham, S.T. Santhiya, P.M. Gopinath and A. Ramesh, 2001. Effect of Spirulina fusiformis on cyclophosphamide and mitomycin-C induced genotoxicity and oxidative stress in mice. Fitoterapia, 72: 906-911.
PubMed  |  

Reitman, S. and S. Frankel, 1957. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am. J. Clin. Pathol., 28: 56-63.
CrossRef  |  PubMed  |  Direct Link  |  

Roy, A.V., 1970. Enzymes in clinical chemistry. J. Clin Chem., 16: 431-439.

Scartezzini, P. and E. Speroni, 2000. Review on some plants of Indian traditionalmedicine with antioxidant activity. J. Ethnopharmacol., 71: 23-43.
PubMed  |  Direct Link  |  

Takeoka, G.R. and L.T. Dao, 2003. Antioxidant constituents of almond [Prunus dulcis (Mill.) D.A. Webb] hulls. J. Agric. Food Chem., 51: 496-501.
CrossRef  |  Direct Link  |  

Trease, G. and S.M. Evans, 2002. Pharmacognosy. 15th Edn., English Language Book Society, Bailliere Tindall, London, pp: 23-67.

Venkatesan, N. and G. Chandrakasan, 1995. Modulation of cyclophosphamide-induced early lung injury by curcumin, an antiinflammatory antioxidant. Mol. Cell Biochem., 142: 79-87.
PubMed  |  

WMA and APS, 2002. Guiding principles for research involving animals and human beings. Am. J. Physiol.: Regul. Integr. Comp. Physiol., 283: R281-R283.
CrossRef  |  PubMed  |  Direct Link  |  

Design and power by Medwell Web Development Team. © Medwell Publishing 2024 All Rights Reserved