Abstract: The reaction of agronomic and reproductive characters of fourteen cowpea breeding lines was evaluated under Meloidogyne inchognita inoculation. Significant differences (p>0.05) was recorded for most characters evaluated. The high degree of variation in seed weight was confirmed by the Coefficient of Variability (CV%) for seed yield. Conversely, the number of days to first flowering recorded a low variability (CV%), this attest a similar response among the breeding lines. The number of pods plant ¹ and loculi was high in IT 568, pod length was maximum in IT 625. The study indicated that under Meloidogyne inchognita inoculation, earliness among the breeding lines was directly influenced by some characters. In addition the number of loculi pod ¹ was influenced by the number of trifoliate, seeds pod ¹, fodder weight plant ¹ and pod weight, pod wall weight and root weight. The stepwise contribution of characters to seed weight returned the fodder weight plant ¹ as most important character. The number of pods plant ¹ (Y) was influenced largely by the contribution of fodder weight plant ¹ and pods plant ¹. The study indicated that both agronomic and reproductive are largely influence by inoculation of Meloidogyne inchognita. IT 568 and IT 2246-4 were identified for seed yield potential under Meloidogyne inchognita inoculation.