Abstract: This study aimed to determine the relationship between the use of information systems and capability Organization of managers at Khuzestan water and Power with descriptive-correlation methods. The Statistical Society of the organization’s managers was totally 200 people. The 131 people as a sample accordingly were selected by random sampling. In order to collect Information two standard questionnaires were applied: Mishra and Spritzer empower and the researcher made information system questionnaires. The face validity and content validity of those questionnaires were approved respectively, by respondents and the supervisor and some experts. Reliability of both questionnaires by using Cronbach’s alpha coefficient for the first and second questionnaires was calculated respectively as 0.88 and 0.92. In order to analyze the data, descriptive statistics and inferential statistic tests also were used which includes Pearson, Spearman correlation and simple regression analysis. The results indicated that there is a significant positive relationship between the use of information systems and managers capabilities at organization. Moreover, all the empowerment dimensions of managers including competency, autonomy and efficacy, trustworthy had a significant and positive relationship with application of information systems. In the model in accord with the regression components: competence (β = 0/456), autonomy (β = 0/260), effectiveness (β = 0/384), significance (β = 0/370) and validity (β = 0/273), of manager capabilities in anticipating of the use of information systems were effective.