Abstract: This study attempted to ascertain if Knowledge Management (KM) and Accounting Information System (AIS) positively affecting job satisfaction. Also, this study aimed to determine if there is mediating effect of Knowledge Management (KM) on the relationship between accounting information system and job satisfaction. As demonstrated by the empirical findings, there appears theoretical effect of KM and AIS on job satisfaction based on the comprehensive utilisation of obtained and analysed statistical data. Smart PLS-2 was used for analysis. A total of 350 respondents employed in the Jordanian industrial SMEs were selected as sample. With respect to the construct of KM, AIS and job satisfaction, the outcomes demonstrate a high level of positive significant linkage between job satisfaction and every one of the two constructs. Nonetheless, the theoretical and empirical explanations have to be provided. It is expected that this research will contribute to literature as it reduces the gap on the substantial impact of KM and AIS on the job satisfaction and the associated implications of the relationship.