Abstract: Human Neutrophil Elastase (HLE) is a serine protease which is released from neutrophils in response to inflammatory stimuli. Thirteen azetidinone derivatives were synthesized and HLE interaction was evaluated by spectrophotometer method. Part of them are active, whereas all the compounds have no cytotoxic activity.
Mariafrancesca Buonerba , Anna Capasso , Annamaria D’Ursi , Giovanni De Martino and Carmela Saturnino , 2005. Preliminary Studies of a New Class of Azetidinones Compounds as Potential Hle Inhibitors . International Journal of Molecular Medicine and Advance Sciences, 1: 4-6.