Authors : Sylver Catherine S. Abarca, Norhana B. Basir, Damra B. Hassan, Czarina Mari P. Shariff and Beaven Andrew A. Atienza
Abstract: This study aimed to determine the effectiveness of durian in increasing the platelet count of white mice. Pre and post-test design was used. Subjects were conditioned and randomly selected: 5 Balb/C mice each for group. Initial platelet count was done three days before administration of 1 mL blended durian on experimental group. The control group not administered was fed with the same pellet and water daily. After three consecutive days final platelet counts were obtained. Results showed notable increase in the platelet count from 187.000 (initial count) to 311.600 (final count) on Balb/C mice after ingesting durian flesh. The initial mean platelet count of mice before administration of the durian preparation is iE = 187.200×10 g L–1. After 3 consecutive days of treatment, it significantly increased from fE = 187.200×10 g L–1 to iE = 311.600×10 g L–1. With a difference of iE-fE = 124.400×10 g L–1 in the platelet reading, this represents the effectiveness of the Balb/C mice in increasing platelet count. This remarkable result goes to show that durian flesh is effective in increasing platelet count of mice. For future researchers, it is recommended that there is a need of increase in terms of dosage, days of administration, the number of test subjects, the use of other varieties of durian and as well as the other parts of durian fruit for effectiveness in the increase of platelet count[1].
Sylver Catherine S. Abarca, Norhana B. Basir, Damra B. Hassan, Czarina Mari P. Shariff and Beaven Andrew A. Atienza, 2020. The Effectiveness of the Flesh of Durian (Durio zibethinus) in Increasing Platelet Count on Balb/C Mice (Mus musculus): A Prospective Study. International Journal of Tropical Medicine, 15: 36-38.