Authors : Basaran Karademir, Guler Karademir, Serdal Tarhane, Unal Ciftci, Evren Koc, Yusuf Ersan and Kadir Bozukluhan
Abstract: This study was carried out to determine the changes of Cu, Zn, Fe, Ca, Mg, K and Na levels in liver during treatment of oral ampicillin in mice. The investigation was supported by serum ALT and AST enzyme activities, serum Total Protein (TP), Albumin (ALB), Globulin (GLB) levels determinations. Twenty one male Swiss albino mice (weighing 28.36±2.33 g, aged 4 months) were used for this study. The standard commercial diet was given to all groups. First group (A) were used control and took only tap water. Other groups were received water with ampicillin. Dose of ampicillin for second (B) and third (C) groups were as follows; 8 and 40 mg/100 mL in drinking water. Dry ashing method and Flame Atomic Absorption Spectrometer (FAAS) were used for determination of minerals. Statistically significant increase (minimum p<0.05) for Cu, Ca and Na and decrease for K were observed. Significant positive correlation between Cu-Ca, Cu-Na, Zn-Mg, Ca-Na, Mg-K (minimum r = 0.450, p<0.05) and negative correlation between Cu-K (r = 0.456, p<0.05) were observed. There was a significant difference in AST levels of groups (p<0.001) but not other serum parameters of ALT, TP, ALB and GLB. These results indicate that oral ampicillin treatment affect liver Cu, Ca, Na and K levels. Therefore, this fluctuation must be considered on ampicillin applications during antimicrobial therapy.
Basaran Karademir, Guler Karademir, Serdal Tarhane, Unal Ciftci, Evren Koc, Yusuf Ersan and Kadir Bozukluhan, 2009. The Effect of Oral Ampicillin Applicaitons on Liver Mineral Status. Journal of Animal and Veterinary Advances, 8: 1846-1850.