Journal of Animal and Veterinary Advances

Year: 2010
Volume: 9
Issue: 4
Page No. 848 - 852

Pharmacokinetics of Cefquinome in Camels

Authors : A.Y. Al-Taher

Abstract: The Pharmacokinetic characters of cefquinome were studied in camels following single intramuscular administration of 1 mg kg-1 b.wt. Cefquinome concentrations in serum were determined by microbiological assay using Micrococcus luteus (ATCC 9341) as test organism. After intramuscular administration, the mean peak serum Concentrations (Cmax) was 1.23 μg mL-1 and achieved after (tmax) 4.25 h. The absorption half life (tl/2(ab)) was 4.35 h and the elimination half-life (tl/2(el)) was 10.24 h. The Mean Residence Time (MRT) was 16.74 h and area under curve from zero time to infinity (AUC0-∞) was 20.37 μg/mL/h. The serum concentrations of cefquinome along 24 h post-injection in this study was exceeding the MICs of different susceptible micro-organisms responsible for serious disease problems. These findings indicate the suitability of successful use of this antibiotic in camels. A recommended single daily dose of 1 mg kg-1 of cefquinome given intramuscularly can achieve quite therapeutic concentrations in serum, that exceeding the minimal inhibitory concentrations against different susceptible pathogens.

How to cite this article:

A.Y. Al-Taher , 2010. Pharmacokinetics of Cefquinome in Camels. Journal of Animal and Veterinary Advances, 9: 848-852.

Design and power by Medwell Web Development Team. © Medwell Publishing 2022 All Rights Reserved