Abstract: The objective of the present research was to evaluate hemogram, haptoglobin and clotting factors indices in cattle affected with acute and chronic peritonitis. About (88) local cattle breed, 2-8 years old of both sexes were used in this study among these animals (23) were affected with Traumatic Reticloperitonitis (TRP), (18) animals suffering from acute ruminitis due to ruminal overload (21) animals were suffering from sever tympany that needed trocarization and (16) show sings of chronic peritonitis as a sequel of ruminatomy. Ten clinically normal local cattle breed were served as control group. Results indicated that clinically diseased cattle exhibited different clinical sings which were varying in degree with the severity and extent of the peritonitis. Statistically significant increase (p<0.05) were encountered in PCV and TLC in cattle exhibited acute peritonitis. Cattle affected with acute peritonitis show nutrophelia and lymphocytopenia. Eosinophelia were indicated in cattle affected with acute riminitis and monocytes were increased significantly in animals affected with chronic peritonitis. Results were also showed significant decrease (p<0.05) in the mean values of total platelets count in cattle affected with acute peritonitis compared with normal control and animals affected with chronic peritonitis. Values of mean platelets volume, platelets distribution width, prothrombin time and partial thrombpplastine time were increased significantly (p<0.05) in animals affected with acute peritonitis. Clotting time was only increased significantly (p<0.05) in cattle affected with TRP. Serum values of fibrinogen and habtoglobin in control and diseased cattle indicated significant increase of fibrinogen (p<0.05) in all diseased cattle whereas habtoglobin increased significantly (p<0.05) in animals affected with acute peritonitis.