Abstract: Ghrelin is a growth-hormone releasing lipopeptide that was shown to regulate of lipid and carbohydrate metabolism and appetite. Brucellosis characterized by fever, headache, night sweats, extreme tiredness, chills and weight loss and anorexia. This research aimed to investigate the changes of ghrelin concentrations in blood of brucellosis patients 19 brucellosis patients and 16 healthy subjects with similar ages were randomly selected as control group. Serum levels of acylated ghrelin were evaluated on blood samples of the participants by Radio-Immunoassay Methods. The results showed acylated ghrelin was significantly changed in patients with brucellosis (8.9±2 pg mL-1) compared with controls (39±15.5 pg mL-1). There is no data showing ghrelin in Brucellosis in literature so far. The first evaluated results showed that appetite decrease in Brucellosis might be due to circulating level of ghrelin decrement.
Nermin Kilic and Suleyman Sirri Kilic, 2012. Decreased Levels of Ghrelin in Brucellosis. Journal of Animal and Veterinary Advances, 11: 1552-1554.