Authors : Yong-Xue Sun, Hai-Yan Zhao, Yu-Jing Liu, Zhen-Qing Dai and Bing-Hu Fang
Abstract: Toxicokinetics of trichothecene mycotoxin, T-2 toxin, HT-2 toxin and T-2 triol were determined in seven swine, after intravenous administration (i.v.) of T-2 toxin (0.5 mg kg-1). The T-2 toxin, HT-2 toxin and T-2 triol plasma concentrations were analyzed by HLPC-MS/MS from 2.5 min to 6 h. The mean pharmacokinetic parameters for T-2 toxin, HT-2 toxin and T-2 triol were respectively: half-life (t1/2λZ) 11.7, 37.7 and 25.6 min; areas under the plasma concentration-time curves (AUC0-00): 16499, 4619 and 11011 min ng mL-1. Following i.v administration, times to observed maximal concentration (Tmax) were 2.5, 2.5 and 7.5 min, respectively. No T-2 tetraol was detected at all sampling times. The total body Clearance (Cl) and the apparent steady-state volumes of distribution (Vss) for T-2 toxin were 0.662 L kg-1 and 0.038 L/min/kg. This study demonstrated that T-2 toxin is rapidly removed from the blood followed by its fast conversion to metabolites.
Yong-Xue Sun, Hai-Yan Zhao, Yu-Jing Liu, Zhen-Qing Dai and Bing-Hu Fang, 2012. Toxicokinetics of T-2 Toxin, HT-2 Toxin and T-2 Triol after Intravenously Administrated T-2 Toxin in Swine. Journal of Animal and Veterinary Advances, 11: 1977-1981.