Authors : Guanyu Che, Yang Liu, Yixue Sun, Bin Guo and Xueming Zhang
Abstract: The importance of ETS transcription factor Etv5 on the self-renewal of Spermatogonial Stem Cells (SSCs) has been well documented recently. Previously, the researchers reported that its peer Etv4 remained at a low level during the normal sexual maturity in mouse. It’s well known that the development of spermatogonia and the expression of the regulatory molecules could be changed during the regeneration after damage of the seminiferous epithelia. To test whether the expression of Etv4 was also altered in male reproductiove system after damage, expressions of Etv4 in testis and epididymis were examined in Busulfan-Treated Mouse Model. Mouse testis and epididymis were collected on the 0th, 3rd, 5th, 8th, 10th and 18th days after busulfan injection, respectively. The effect of busulfan treatment was confirmed histologically. In testis, Etv4 mRNA declined evidently on day 5 and 8 and decreased significantly on day 10 (p<0.05) while it remained a relatively higher level at all time points in epididymis and decreased significantly on day 8 (p<0.05). Collectively, Etv4 might be involved in the regeneration of seminiferous epithelia and the maturation of sperm in epididymis.
Guanyu Che, Yang Liu, Yixue Sun, Bin Guo and Xueming Zhang, 2012. Expression of ETS Transcription Factor Etv4 in Busulfan-Treated Mouse Testis and Epididymis. Journal of Animal and Veterinary Advances, 11: 2801-2803.