Abstract: In this study, 207 healthy children groups from 0-6 years old was subjected to analysis of subclinical infection of EV71, 25 subclinical infection blood selenium level of 45 healthy people and 41 HFMD patients were compared. Positive rate of subclinical infection of anti-EV71 IgG antibody was 10.8% (17/157) and 26% (13/50), respectively in two healthy children groups, the 0-3 and 4-6 years old groups that of IgM anti-body were 15.2% (24/157) and 8.0% (4/50), respectively. There was highly significant difference (p<0.01) in the positive rate of anti-EV71 IgG and IgM antibodies in both age groups. The positive rate of EV71 nucleic acid in 28 patients with positive anti-EV71 IgM antibody was 89.2% (25/28). The blood selenium level of 41 HFMD patients, 25 subclinical infection and 45 healthy people were (μg g1) 0.081±0.01, 0.132±0.031 and 0.137±0.024, respectively. There was highly significant difference (p<0.01) in blood selenium level between the HFMD group and two other groups compared by Chi-square (χ2) test. A large number of children under the age of 6 years had EV71 subclinical infection. The patients with EV71 infection and low blood selenium were susceptible to HFMD.
Guo Guangzhou, Zhang Dongxiao, Yang Fan, Wang Bing, Liu Tao, Xue Caifang and Zhang Renli, 2012. Blood Selenium of Low-Level Associated with Development of Hand-Foot-Mouth-Disease. Journal of Animal and Veterinary Advances, 11: 381-385.