Authors : K.E. Mahmoud, T.M. Shalahmetova, Sh. N. Deraz and B.A. Umbayev
Abstract: Antioxidant defense were studied in liver and kidney of male albino rats which daily received deionized water to drink (group I, control) or solutions of ammonium metavanadate (AMV; 0.15 mg V mL-1) groups II; crude oil (CO; 0.5 mL kg-1 bw ip) group III and AMV-CO at the same concentrations as in groups II, III and IV for 3 weeks period. The results revealed significant increase in lipid peroxidation (p<0.01) and concomitant decrease (p<0.001) in Superoxide Dismutase (SOD) activity in liver and kidney of rats treated with AMV or/and CO. Glutathione-S-Transferase (GST) activity significantly decreased (p<0.001) in liver and increased (p<0.001) in kidney after AMV or AMV-CO treatment whereas Glutathione (GSH) concentration decreased (p<0.001) in both these organs. In CO treatment, GST activity significantly (p<0.01) increased in liver and was unchanged in kidney while GSH concentration decreased in kidney and was unchanged in liver. Activities of serum aminotransferases were significantly (p<0.001) increased following AMV or/and CO treatment to normal rats. Vanadium administration at this dose showed signs of toxicity on the treated animals as evidenced by some deaths, decreased weight gain, the toxicity was more pronounced by combined vanadium and crude oil treatment whereas crude oil alone did not show any visible signs of distress or intoxication. These data indicated that kidney is more vulnerable to the caused by the AMV or/and CO-induced oxidative stress than liver as well as that the oxidative stress at co-exposure to AMV and CO may be more markedly advanced than at separate exposure.
K.E. Mahmoud, T.M. Shalahmetova, Sh. N. Deraz and B.A. Umbayev, 2012. Antioxidant Biological Effects of Crude Oil and its Inorganic Component (Vanadium) in Liver and Kidney of Rats. Journal of Animal and Veterinary Advances, 11: 692-699.