Abstract: This study was performed to evaluate the protective role of pentoxifylline in preventing the detrimental effect of cadmium on the rat fertility. Thirty rats were assigned into five groups. Control group was daily administered saline for 60 days. Cadmium group was administered daily with cadmium chloride for 30 days then with saline only for 30 days. Pentoxifylline plus cadmium group was administered daily with saline for 30 days then with CdCl2 plus pentoxifylline for 30 days. Pentoxifylline pre-cadmium group was administered daily with pentoxifylline for 30 days then with CdCl2 for 30 days. Pentoxifylline post-cadmium group was administered daily with CdCl2 for 30 days then with pentoxifylline for 30 days. Cadmium caused a significant weight reduction in the body and reproductive organs; serum and testicular testosterone, zinc; antioxidant enzymes and semen characteristics while it caused significant increase in testicular cholesterol and Malodialdehyde (MDA). Histopathologically cadmium caused impairment in the testes. Pentoxifylline treatment improved the estimated parameters. It could be concluded that the pentoxifylline treatment improved the evaluated parameters and cloud be used for protection against cadmium toxicity.
Abdeldayem Zakaria and Khalid A. Al-Busadah, 2015. Pentoxifylline Efficiency in Protecting Testes Against Cadmium Toxicity. Journal of Animal and Veterinary Advances, 14: 18-29.