Authors : B.S. Okediran, O.A. Olatunde, K.O. Oladesu and E.S. Samuel
Abstract: The toxicity of mixed pyrethroids insecticides to mammalian animals has received much attention in recent years because animals exposed to these insecticides exhibited changes in their physiological, haematological and biochemical activities beside other pathological features. The study aimed to investigate the responses of male albino rats under stress of inhalational exposure to mixed pyrethroids on the haemogram, lipids, electrolytes, liver and kidney functional indices. Twenty male rats were maintained on standard healthy laboratory conditions and had free access to food and drinking water ad libitum. The rats were divided into four equal groups A-D. The group A represented the healthy control rats, while groups B, C and D were inhalationaly exposed to mixed pyrethroids at doses of 30, 60 and 90 mg kg–1 respectively for 2 weeks. At the end of the exposure, blood sample was collected for haematological studies while serum was used for biochemical analysis. There was significant reduction in PCV, MCV, MCH and MCHC compared to the healthy control group while total leucocytes counts was significantly elevated. There was also significant increase in the activities of ALT, AST as well as marked hypoproteinaemia, hypoalbuminaemia and azotaemia indicating liver and kidney dysfunction. However, the lipids and the electrolytes were equally perturbed. It was concluded that exposure to mixed pyrethroids predisposes the male rats to stress, altered haemogram with varying disturbances of various biochemical parameters resulting in death of rats exposed to highest dose of the mixed pyrethroids.
B.S. Okediran, O.A. Olatunde, K.O. Oladesu and E.S. Samuel, 2020. Responses of Male Albino Rats under Stress of Mixed Pyrethroids. Journal of Animal and Veterinary Advances, 19: 75-81.