Abstract: The aim of this research was to design and develop a website, technology and method for assisting Hearing Impaired (HI) people to learn Thai vocabulary. The website included a new word module, a translation and voting module to determine the most popular sign language interpretations. The most preferred will become the Thai sign language standard for teaching Thai vocabulary. The sample groups were selected by purposive sampling of 30 hearing impaired students in grades 5th who know Thai sign language and 9 expert reviewers who also understand Thai sign language. The experimental sample was divided into 2 groups: An expert group and a user group. The expert group completed two questionnaires: certification of the User Interface (UI) and preference of Thai sign language word interpretation standard. The user group also completed 2 questionnaires: user satisfaction with the UI and user test of the learning content to determine their learning outcome. This research was analyzed using descriptive statistics (Mean, SD, percentage and t-test). The results showed that the experts have accepted and certified the UI and also the content. The experts preferred the sign language standards which were most effective in explaining Thai vocabulary to HI learners. Those standards selected by the experts were 62.40% from the invented sign language words from the Setsatian School for the Deaf, 28.92% were sign language equivalents used by the Thailand Association of the Deaf Institute and 7.68% were sign language translations for Thai vocabulary from other schools. The users also accepted and certified the UI and content. The results also indicated that the HI student user’s learning outcome was improved after using this system to learn Thai sign language vocabulary. The data were analyze utilizing statistical t-test at p<0.01 level.