Abstract: In this study, the purpose is to apply aromatic inhalation therapy to nurses working three shifts who experienced work overload as well as sleep lack and chronic fatigue in order to inspect the outcomes of aroma on the fatigue and irregular sleep pattern of the registered nurses. As quasi-experiment study on the non-equivalent control group, this study were collected from June 1st, 2013 to July 15th, 2013 on the experimental group of 30 registered nurses and the control group of 30 registered nurses who research shifts at C University hospital in Seoul. This study analyzed using descriptive statistics, X²-test and Independent t-test by use of SPSS WIN 18.0, a statistics program. This study recognizes the impacts of aromatic inhalation therapy on level of fatigue and the quality of sleep of working three shifts nurses; the experimental group getting aromatic inhalation therapy enjoyed quality sleep while feeling less fatigue. It is assumed that the aromatic inhalation therapy can be requested as interventions to working three-shifts nurses to improve their sleep while reducing fatigue. In addition, this study makes a recommendation for further studies on the selecting of aroma oil on the way of interventions based on the individual general characteristics of the working three shifts nurses and the various wards they research at. It is also recommended that sleep programs is developed that can help manage the variables identified in this study and that follow-up studies are conducted to verify the model.