Authors : Murashko Tatyana, Emanova Olga, Smirnov Vladimir, Ivanov Alexey and Smirnov Ivan
Abstract: We studied diuretic and saluretic effects of new synthetic origin phenolic glycosides in comparison with the leader-structure arbutin. Investigation of diuretic and saluretic activity of hydroquinone-O-β-D-glucopyranoside (arbutin) 2-methoxy-4-formylphenyl-O-β-D-glucopyranoside and phenyl-O-β-D-glucopyranoside was conducted on white laboratory rats. Animals received drug with increasing dose over 14 days. Baseline diuresis after administration of 2 mL of distilled water of experimental group accepted as a control. The quantity of urine output was measured a day after administration of the test substances. The concentration of sodium and potassium ions in the urine were determined by flame photometry. The data obtained indicate that investigated glycosides has high diuretic activity. We observed dose-dependent effect of substances. The 2-methoxy-4-formylphenyl-O-β-D-glucopyranoside it is the most promising of the investigated in this study the synthetic compounds.
Murashko Tatyana, Emanova Olga, Smirnov Vladimir, Ivanov Alexey and Smirnov Ivan, 2017. Development of New Aquaretic Drug Based on Phenolic Glycoside Structure. Journal of Engineering and Applied Sciences, 12: 6398-6401.