Abstract: The factories of tomorrow are not going to look like the ones of today. Automobiles and medical devices will be fabricated by 3D printing. Internet of Things (IoT) and Internet of Every Thing (IoET) shall dominate. Automation, analytics, cloud and cognitive computing are already changing the business paradigms. Royal Bank of Scotland cancelled their 3 years contract with Indian IT organization Infosys and 3000 jobs were affected due to the influence of Brexit. Due to an unfavorable Foreign exchange shock after Brexit led to Indian automobile major Tata Motors reporting a 57% plunge in consolidated net profit in the first quarter of FY 2016-17. Banking, financial services and insurance sector shall operate fully through disruptive client online platforms such as Change-The-Bank (CTB). India’s largest IT services company Tata Consultancy Services (TCS) is taking on global IT giant accenture by focusing on Change-The-Bank (CTB) platform wherein, it helps the banks to create revenue streams by leveraging new business models. This recent focus by Tata Consultancy Services (TCS) on Change-The-Bank (CTB) platform differentiates from the traditionally focused Run-The-Bank (RTB) services wherein the suggestion to clients was to make the most of efficiencies, reduce costs and boost profitability. These are few examples of companies who are taking on the head winds of a shifting world paradigm. So, the substantial complexity for all organizations revolves around how will they nurture and develop their businesses effectively and profitably in this constantly shifting world paradigm?