Abstract: Information system audit has contributed greatly to the construction and operation of a safe and reliable information system. It is necessary to establish a proper information system audit model for the establishment and operation of smart work environment and to carry out the audit, so that, the informatization project can be successfully performed. Information security must be implemented and managed in a smart work environment that guarantees continuity of research even in a physical space that cannot be controlled by enterprises and organizations. Therefore, an information security audit model that can be used to build a secure smart work environment is needed. However, in the existing information system audit, the information security implementation is not constituted as a separate control area and there is no information security control framework specialized in the smart work environment. In this study, it is proposed the checklists and an information system audit model for technical information security audit suitable by using information security management system in smart work environment. In order to verify whether the proposed information security checklists meet the purpose of smart work information security audit, it is verified the suitability through questionnaires of the IT industry practitioners.