Abstract: The purpose of this study is to determine the mechanism in antibacterial activity of medicinal plant against Candida albicans. In order to best anti-Candida albicans effects for nine kinds of medicinal plant, Artemisia apiacea Hance, Artemisia annua, Brassica oleracea L., Coptis chinensis, Pogostemon cablin Bentham, Loranthus chinensis Danser, Ulmus macrocarpa Hance (bark). Medicinal plant ethanol extracts were examined by disc diffusion method for anti-Candida albicans activity and used fluconazol (50 mg/mL), 99% ethanol as a positive controls. We measured the area of clear zone and evaluated that the larger size of the area was more effectives against Candida albicans. The result of this study, Artemisia apiacea Hance value was highest as 38.2 mm and next Ulmus macrocarpa Hance (bark) 32.8 mm. This result is a result which is equivalent to about 97% when compared to 39.1 mm of the fluconazol (50 mg/mL) positive control. The present results, along with the observation, suggested that Artemisia apiacea Hance and Ulmus macrocarpa Hance (bark) extracts could be anti-Candida albicans agents to cause the infection candidiasis in humans.
Jeong-Sook Park, Mi Kyung Park and Jae-Hyeok Lee, 2018. Mechanism in Antibacterial Activity of Medicinal plant against Candida albicans. Journal of Engineering and Applied Sciences, 13: 372-375.