Abstract: The significant development of science and technology particularly in medical treatment break through has offered great potential and new hopes to treat some genetic disease and disorders. Somatic gene therapy for example is important discovery which offeres promising successful treatment in several genetic disorders. Nonetheless, such technique has given rise to ethical and legal issues. In view of this point, this study seeks to explore in the light of Islamic rulings on the ethical issues surrounding somatic gene therapy. It would take an inspiration from the Qur’an and Sunnah (tradition of the Prophet Muhammad PBUH) principles in examining the Islamic medical ethics principles. These underlying principles are important to maintain flexibility to respond to this trial. Its position is then analyzed within the application of Maqasid Al-Syariyyah (Objectives of the Shari’ah) and the branches of Qawaid Fiqhiyyah (Islamic Legal Maxims) to draw the parameters of somatic gene therapy. With regard to Malaysia position, current fatwas (Islamic verdict) shall then high lighted. This study adopts qualitative method using content and doctrinal analysis approach. This study concludes that somatic gene therapy is ethically permissible in Islamic doctrine as it confers benefits to the public at large. However, the permissibility is subject to certain restrictions and stringent requirements. Thus, thorough assessment need to be observed before somatic gene therapy decision making is made. Therefore, given Islam is the official religion and Muslim is the majority in Malaysia, it is vividly important for Malaysia to also having comprehensive Islamic framework governing somatic gene therapy.