Authors : Iman Mehdi Mohammed Hasan
Abstract: A new series of chalcone derivatives was synthesized then polymerized theirs due to resins. Starting from (E)-3-(benzo[d] [1, 3] dioxol-5-yl)-1-(4-hydroxyphenyl) prop-2-en-1-one [1] which reacts with di bromo ethan preperated [C2] then reacted with secondary amines(piperidine, morpholine, piperazine, 4-methyl piperidine) to prepare [C3-C6] as monomers which polymerized using AIBN initiator due to resins [C7-C10]. All proposed structure were supported by FTIR, some derivatives evaluated by H1-NMR, elemental analysis, thermal analysis (TGA, DSC) and evaluated for anticonvulsant activity by MES method, most of derivatives were found to be more or comparable potent than the reference standard drug.
Iman Mehdi Mohammed Hasan , 2019. Synthesis, Characterization with Studing Anti Convulsant Activity of Some New Resins by Free Radical Polymerization Starting from Chalcone Derivatives. Journal of Engineering and Applied Sciences, 14: 10472-10481.