Abstract: This study highlights the performance of cathodic protection system for buried pipe in different soil environments and explores the experimental results obtained from studying the factors affecting of impressed Current Cathodic Protection system (ICCPs). During the field survey, 4 stations of cathodic protection were studied at different regions along the oil exporting pipeline in Missan City, Southern of Iraq, information was gathered that necessary for designing cathodic protection system. Site conditions were applied on modelling of impressed current cathodic protection the main factors include temperature, moisture content and anode position relative to cathode (pipe) were studied to assess how different variables affected on performance of ICCP system. The advanced statistical techniques employed Response Surface Methodology (RSM) based on Central Composite Design (CCD) was utilized to Design of Experimental (DoE) for ICCP Model. The results of ICCP Model show that the significant factor is moisture content where act on current required for protection. Moreover, the temperature of environment is playing a worthy role in performance of ICCP system, the cathodic current tends to increase as the environment temperature increased. Considered the anode position is a significant factor in pipe-to-soil potential readings. In other hand required current for protection decrease about by 88% for coated pipe rather than being uncoated.