Abstract: The economic profitability of seed yam production by the yam minisett technique was investigated in humid south west Nigeria. Farmers were drawn from across Ondo State with geographical coordinates of 4028`E to 6015`E and 5045N to 8030`N in South West Nigeria and given the training in the technically improved seed yam production in 1999. Three of the farmers were given agricultural loan of one hundred and twenty thousand naira (#120,000.00) each to go into commercial seed yam production on one hectare for three years 2000, 2001 and 2002. Profitability analysis was carried out to assess the profitability of seed yam production for the three years.. The total costs of production in year one, year two and year three were #123,718.00, #142,680.00 and #130,278.00 respectively with revenue of #256,000.00 in each year. The net farm income were #132,282.00 for first year #113,320.00 for second year and #125,722.00 for the third year while the benefit cost ratio for production was 1.97 which confirmed the project to be highly profitable. The three farmers fully repaid their loan obligation at the end of the three years with high profits accruing to them. The production of seed yam by the minisett technique has made the planting materials of yam more abundant and it is a major breakthrough in yam production in Nigeria and other yam producing tropical regions.