Abstract: Substance abuse has become a colossal problem in Nigerian tertiary institutions of learning. With sampled students of Lagos State University in Nigeria (n = 132), this study examined the problem of substance abuse among the Nigerian University students. The investigations revealed that alcohol, cigarette and marijuana were the commonest abused substances by these youths. The findings showed that peer groups were the important factor which encouraged the involvement of the university students in substance abused. The study discovered that the counseling department of the university was not effective in assisting the students affected with the problem of substance abuse and therefore cannot be of any fruitful help. It is recommended that families should be educated on the need to educate their young members on the dangers of the substance abuse. Parenting as an art must be structured to give guidance to the children. Counseling centres must be established and the counselors must be constantly placed on on job training to assist the students who are addicted to the substances abuse. Campaigns against the abuse must be intensified in the society, especially on the university campuses and there must be university strict disciplinary actions against the student substance abusers. The inclusion of drug education in the curricula must be done at all levels of education. The job opportunities must be provided to gainfully employ the potential drug substances sellers. Finally, ongoing researches on drug/substances abuse are encouraged continuously to monitor the trends of the abuse and ways out of this social plague.