Abstract: The present study aims to assess ghrelin, obestatin hormones levels and ghrelin to obestatin ratio in patients with hypertension disease and to find out a possible relationship between obestatin, ghrelin level with different criteria including, systolic blood pressure, diastolic blood pressure and Body Mass Index (BMI) in patients with hypertension disease and compared with healthy controls. The 69 patients are diagnosed with hypertension disease (33 males and 36 females) and 20 control healthy subjects (10 males and 10 females) having no history of diabetes mellitus, renal failure and other disease enrolled in this study. The patients are selected from both sexes (males and females) their ages ranged between 40-70 years old. Patients with hypertension disease are recruited from Al-Sader teaching city in Al-Najaf Al-Ashraf Governorate/Iraq. Results of the present study in general revealed a significant increase (p<0.05) in obestatin level in patients with hypertension diseases in a comparison with control group and significant decrease (p<0.05) in ghrelin level in patients with hypertension disease comparing with control group and ratio of ghrelin to obestatin ratio was decreased in patients undergo from hypertension when compared with control group. The result showed a positive correlation among obestatin, systolic pressure, diastolic pressure and Body Mass Index (BMI) with negative correlation between gherlin, systolic pressure, diastolic pressure and negative correlation between ghrelin to obestatin ratio with blood pressure. The present study concluded that ghrelin, obestatin and ghrelin/obestatin ratio might play role in blood pressure regulation.