Abstract: This study was a research and development study, aimed to develop the Administration Management Model on infectious waste of Tambon health promoting hospital, Kalasin Province. The samples comprised 32 officers as a agent who is in the Tambon health promoting hospital Namon District Kalasin Province's population which have been selected by a purposive sampling technique. This study were participatory action research as a method for officers participation in infectious waste management, conducted under four participatory frameworks including planing, decision making, practice and evaluation. The research instruments included questionnaires, group discussions organization meetings and observation. The data collection was analyzed by frequency, percentage usage and t-test. The study results are as following: the Administration Management Model (Kalasin Model) development on infectious waste management was rated as a high efficiency. The officers of Tambon health promoting hospital had knowledge and behavior on infectious waste management after training was rated higher that before training (p<0.05).