Abstract: The aim of this study was to investigate the relationship between knowledge management and organizational entrepreneurship in the Ministry of Sport and Youth of the Islamic Republic of Iran. This research has purpose and descriptive-correlation and it was carried out. The population included all experts of the Islamic Republic of Iran’s Physical Education Organization, a total of 299 people, according to estimates by experts as our sample sample volume 194. Knowledge management questionnaire to collect data from both Lawson and entrepreneurship Marguerite Elizabeth Hill was used. To collect the data, descriptive statistics Kolmogorov-Smirnov Vamarastnbaty considering normal distribution and Pearson correlation test was used. All statistical analyzes were performed using SPSS Software and Exel. According to research findings between knowledge management and organizational entrepreneurship. There is a significant component of its Based on the results, it should be stated that special attention to knowledge management and continuous efforts to improve it as a competitive advantage in the 21st century, organizations to achieve their goals and lead to the capacity for entrepreneurship and improve current processes of the organization will be more successful.