Abstract: This study aims to assess the modern science culture from the scientific thinking skills, habits of thinking sciences and its contributions to the culture of indigenous among high school students of West Sumatra. The analysis was done by descriptive data and inference analysis by using one-way univariat test and linear regression analysis. The results showed that the scientific thinking skills students are at high stage and the habit of scientific thinking of them are at high stage too. The analysis of one-way univariat test showed there is no significant difference on the confidence level of 95% (F 2, 448 = 0.354, p = 0.702) in terms of the scientific thinking skills among high school students based on location of residence, and there is no significant difference on the 95% confidence level (F 2, 448 = 1,116, p = 0.328) in term of the scientifically thinking habit among high school students based on location of residence. The linear regression analysis showed that both independent variable those are culture of modern science variable of students from their scientifically thinking skills and habits, both variables give significant influence on the indigenous science culture about 3.7%. The high variable that contribute to the culture of indigenous science that is the ability to scientifically thinking skills 3.0% and the habits of scientifically thinking 0.7%. The implications of this research are necessary coaching and developing the modern scientific thinking in the high-school student’s level through qualified learning science. Therefore, providing the facilities of learning and improving the quality of teachers should receive high attention.