Abstract: Public well being is a perquisite for sustaining, community job and educational performance of the society which is achievable through physical mental health programs. One of important dimension of sustainable development includes health sectors which has direct influence of human health. This is possible only through healthy and motivated human resources health sector. Thereby, this study was conducted aiming in assessing the mental health status of human resources of shiraz hospitals and community performance it also studies the occupational risk factors, in relation human resources health and relationship between migraine -TTH and their mental health status. The sample size includes 1023 Shiraz hospital staff. The subjects were selected using categorical random sampling method. Data was collected using a questionnaire, which included demographic, occupational and health status of staff. The health status was assessed using GHQ ₂₈ standards. The diagnostic criteria of type of headache were done by using international headache society standards and interview and medical examination by a neurologist (466 individuals). 45.6% of staff had poor mental health, prevalence among male and female were 27.6(16 cases) and 54.3 (380 cases), respectively. Their average score in physical health, anxiety, social functions, depression and general mental health statue were 6.72, 6.67, 6.48, 3.28 and 23.2% respectively. Mental health status had a meaningful relationship with steep pattern, physical activity and job satisfaction. Females had more odds to disorder and results show that headache has a profound effect on mental health status and these two are not independent of each other. Findings indicate that mental health disorders have a high prevalence; thereby authorities and researchers need to pay more attention to this issue, through identifying influential factors and developing intervention programs to improve the situation. To improve the sleep pattern and make facilities available for physical activities, are essential for staff satisfaction. High co morbidity between headache and GHQ requires specific strategy and intervention development.