Abstract: Nowadays in every field related with information and learning, the discussion of change and transformation based on modern technologies like computer is underway. Using virtual training tools is one of the modern opportunities by which the information technology development has empowered medical training. It has been years that valid universities of the world, besides their current training, have been using electronic training courses in the form of distant learning for training their students. Then educational offices and designers have urgent need to the result of those researches that can reveal useful information regarding the function of these systems. In this base the present research intended to do some part of the training credits of physiopathology course by the way of distant e-learning and do functional analysis and examination by comparing its results in comparison with the present classical and attended system. This study was done in the way of randomized clinical trial in the study society of medical students, physiopathology section at Medical Sciences University by choosing 120 students in the way of clustral-randomized in two groups, control group and study group. The control group used the classical methods of attending class and the study group used web based learning facilities for one month. The educational subject of both groups was physiopathology of heart. The professors and students of both groups in this study were Double blind. At the end of one-month period, the students� scores were compared and the polling questioner with Alfa Korenbakh par 65% was filled out. The obtained average score from credit of physiopathology course in control group was 13.05�1.7 and the average score of the study group was 14.08�1.8 that with the performance of Independent sample t-test and with t = 2.1 there was a significant difference between two groups regarding the grade of credit of heart physiopathology course, P-V = 0.033. The examination of the results from students given polling questioner concerning e-learning method showed that the average general satisfaction from the learning period was 3.07 out of 5. Regarding the novelty of this learning system, the obtained results indicated its good effects on the advancement of learning level of medical students. The obtained results from this study and other studies show that web based learning in addition to its specific benefits, causes the advancement of learning level quality and also students� grades. So this method can be used in learning courses and theoretical credits of medical field. But it should be borne in mind that this method is not the complete substitution for all learning courses at university.