Authors : Giulia Bivona , Chiara Bellia , Salvatore Cammarieri , Bruna Lo Sasso , Rosachiara Carollo , Rosalinda Raineri , Gaia Chiarello , Antonietta Caruso and Marcello Ciaccio
Abstract: Cardiovascular diseases often recognize a hereditary-familial genetic risk patterns and a substantial proportion of variability in clinical features of atherosclerosis could probably be explained by genetic factors. Aim of this study is to compare prevalence of factor V Leiden, factor II 20210A, PAI-1-675 4G/5G and MTHFR C677T gene variants in 2 cardiovascular disease clinical features: young acute myocardial infarction (<50 years) and ischemic stroke. Plasminogen Activator Inhibitor-1-675 4G/5G didn�t show significant difference between patients and controls while, between patient groups, the polymorphism was most present in myocardial infarction group than in juvenile stroke. Polymorphisms in Homocysteine metabolism: MTHFR C677T variants was significantly higher in patients with myocardial infarction compared with those affected by ischemic Stroke.
Giulia Bivona , Chiara Bellia , Salvatore Cammarieri , Bruna Lo Sasso , Rosachiara Carollo , Rosalinda Raineri , Gaia Chiarello , Antonietta Caruso and Marcello Ciaccio , 2008. Plasminogen Activator Inhibitor-1-675 4G/5G and Methylenetetrahydrofolate Reductase Gene Variants in Young Acute Myocardial Infarction and Juvenile Ischemic Stroke. Research Journal of Biological Sciences, 3: 1341-1343.