Authors : Peyman Poor Davood , Naser Farhadi and Mohammad Najafizadeh
Abstract: The role of the HLA system in the pathophysiology of primary renal disease is intriguing, but not completely resolved. According to the results of studies links between HLA haplotype and renal failure has been reported. This study was conducted to determine protective and susceptible role of HLA class I genes in end stage renal disease patients. Subjects of this study were 77 individuals from Azerbaijan republic referred to Iran Red Crescent Society clinic in Baku of which were assigned into 2 group, case and control, based on renal disease. Case group were 26 patients with end stage renal disease candidate for renal transplant and controls were 51 healthy subjects. Typing of HLA class I was performed by serologic method. There was no significant difference in age and sex between control and patient groups. The most frequent detected HLA antigens were A2 (41.6%), A3(28.6%), A24(26%) from A loci and B35 (46.8%), B51 (29.9%), B18 (13%) from B loci. Significant association was found between susceptibility to ESRD and HLA-A33, A11, B49 (p<0.05). The findings support the idea that polymorphism of HLA class I may influence the susceptibility to ESRD. We suggested HLA antigen distribution will identify the high-risk patients who are candidates for transplantation.
Peyman Poor Davood , Naser Farhadi and Mohammad Najafizadeh , 2008. Protective and Susceptible HLA Class I Genes in Patients with End-Stage Renal Disease. Research Journal of Biological Sciences, 3: 1344-1346.