Authors : Z.H. Torabizadeh , F. Naghshvar and M. Ghahremani
Abstract: Several studies have demonstrated the biologic and therapeutic significant of Estrogen and Progesterone Receptors (ER and PR) in breast carcinomas. The aim of the current study, was to examine the presence of Androgen Receptors (AR) in breast carcinomas. One hundred ten cases of invasive breast carcinoma from May 2002 to May 2006 were examined using a monoclonal antibody against AR on formalin-fixed, paraffin-embedded archival material. The results were analyzed for correlations with inmmunohistochemically determined ER and PR. The mean age of the patients was 51.3 ± 10.83. Histologic grade was 16, 60 and 24% in grades of 1, 2 and 3, respectively. Forty eight of the 110 cases (43.6%) of invasive carcinoma were AR-positive according to internationally standardized guidelines. No significant association was found between AR expression and histologic grade and age of the patients.
Z.H. Torabizadeh , F. Naghshvar and M. Ghahremani , 2008. Evaluation of Androgen Receptor (AR) Expression in Females with Invasive Breast Carcinoma, Sari, Iran, 2002-2006 . Research Journal of Biological Sciences, 3: 307-310.