Authors : S.H. Hosseini , W. Gaffari Saravi , S.M.B. Hashemi Soteh , M. Zarghami and A. Saljughian
Abstract: Bipolar affective diseases are relatively common affecting about 1-5% of the population worldwide with heritability about 80%. Previous studies supposed the association of heterozygous -thalassemia and Bipolar Disorder (BPD). This study examined this association in Iranian patients. A case-control study recruited 110 patients with BP and 118 subjects with no psychiatric disorders. Total Cell Blood Count (CBC) was undertaken for all subjects. Haemoglobin electrophoresis was only carried out for those who were microcytic in the blood picture (MCV<75 FL). Ten percent of patients and 10.1% of control group were microcytic in their CBC. Haemoglobin electrophoresis revealed 9 out of 110 (8.18%) in patients and 5 out of 118 (4.24%) in control group had haemoglobin A2 elevated between 3.4-7% and identified as minor -Thalassemia. In the present case-control study, no significant linkage was identified comparing the prevalence of heterozygous -thalassemia in two groups. Based on the results presented here, we could not conclude any association between BPD and heterozygous -thalassemia.
S.H. Hosseini , W. Gaffari Saravi , S.M.B. Hashemi Soteh , M. Zarghami and A. Saljughian , 2008. Evaluation of Co-Segregation Between Bipolar Mood Disorder and Heterozygous Beta-Thalassemia in Patients Originated From Iran. Research Journal of Biological Sciences, 3: 798-800.