Abstract: The fragility of the main erythroid cell fractions of the peripheral blood of male albino rats was investigated under hypoxic conditions. Hypoxia was induced by “raising” the animals to an imaginary height of 5000 m above sea level through 10 days. Erythroid cells were fractionated into populations using the sucrose solution concentration gradient method. Cell fragility was studied using the kinetics of acid-induced hemolysis of red blood cells. Increased resistance of cell populations to hemolysis was recorded in the critical periods of adaptation, with a tendency towards normalization of cellular fragility in late periods of exposure to hypoxia.
B.O. Ekpo and I. Elekwa , 2009. The Fragility Studies of the Main Erythroid Cell Fractions of Rats During Hypoxia. Research Journal of Biological Sciences, 4: 289-292.