Authors : Parichehreh Yaghmaei , Shahrbanoo Oryan , Zahra Hojati , Amirhadi Masoudi , Shahab Amini and Elham Amini
Abstract: The effects of co-administration of yohimbine and caffeine on memory impairment induced by clonidine. The effects of yohimbine and caffeine on memory impairment induced by clonidine were measured for memory retention of passive avoidance learning in rats. Post-training intracerebroventricular (i.c.v) injection was carried out in all experiments and optimum doses were identified. The interaction of optimum doses of clonidine, yohimbine and caffeine was investigated on consolidation of step-through passive avoidance memory in rats. Clonidine (2, 4, 6 and 8 μg rat-1) reduced memory retention, yohimbine (4, 6 and 8 μg rat-1) and caffeine (10, 20, 30 and 40 μg rat-1) increased memory retention. Co-administration of the optimum doses of clonidine (6 μg rat-1) and yohimbine (6 μg rat-1), showed a statistically significant reduction in the time of step-through latency (p<0.05). Co-administration of the optimum doses of clonidine and caffeine (30 μg rat-1) showed no significant increase in the time of step-through latency (p>0.2). However, the interaction of caffeine and yohimbine synergistically increased the time of step-through latency. Furthermore, utilization of the three drugs reduced the memory impairment caused by clonidine and potentates consolidation of memory (p<0.05). These results may lay the groundwork for further studies using synergistic effects of caffeine and yohimbine on memory retention.
Parichehreh Yaghmaei , Shahrbanoo Oryan , Zahra Hojati , Amirhadi Masoudi , Shahab Amini and Elham Amini , 2009. Interaction of 2-adrenergic System and Caffeine on Passive Avoidance Learning in Male Wistar Rats. Research Journal of Biological Sciences, 4: 327-334.