Abstract: Successful aesthetic and functional outcomes of any prosthetic reconstruction require an adequate and favorable ridge contour for proper pontic design and implant placement. Often the ridge needs to be reconstructed with bone substitutes. The aim of this study was to compare the quality and quantity of newly formed bone resulting from 3 different types of commercial bone substitutes (Bio-Oss®, Bio-Gen®, PTG®). About 6 round intrabony defects were made with a trephine bur on each of ten tibias. Each defect in each tibia (except one defect in each tibia which served as control) was randomly filled with a bone substitute with or without a resorbable collagen barrier membrane. The animals were euthanized after three months and the proximal part of the tibias containing the defects were prepared for histologic and histomorphometric evaluation. The mean percentage of new bone in the three groups with grafted material was higher than those without grafted material. The mean percentage of new bone and remaining soft tissue in the PTG® group was similar to the Bio-Oss® + collagen membrane group but the bone quality was better in the PTG® group. Application of PTG® does not interfere with the initial healing of the surgical wound.
Golam Ali Gholami, Maryam Tehranchi, Mahdi Kadkhodazadeh, Anahita Ashoori Moghadam, Farzin Ghanavati, Mohammad Reza Talebi Ardakani, Maryam Aghaloo and Fatemeh Mashhadiabbas, 2010. Histologic and Histomorphometric Evaluation of Bone Substitutes in Experimental Defects. Research Journal of Biological Sciences, 5: 465-469.