Authors : M. Dadelahi, G.H. Vaezi and K. Keramati
Abstract: Myristica fragrans plant is one of the herbal plants which has medical and cure effects on nerves. By pay attention to the disadvantages of the psychological drugs for body, the researchers want to have a research on the relations between these drugs and fear. In this study, the researchers put extract of Myristica fragrans (50%) with the 24.53% humidity is the values of (600,300.150 μg per rat) with six sample that each with the value of 1 μL. In the control group, they inject 1 micro L saline to the injection of cerebral ventricular. Also in other positive control group, 20 mg kg-1 Pentylenetetrazol (PTZ) inject to the Intra Peritoneum (IP) after these injections, they evaluate the fear behaviors with the Elevated plus-maze test. The results of this test shows that PTZ is as the positive control group (p<0.05) can increase the residence time in the close arm more than the saline control group. In comparison, the extract of Myristica fragrans is all doses could increase the specified criteria and decrease the residence time in the open arm. But to the statistical way, two doses (600, 300 μg per rat) have the various levels (p<0.05), the saline control group. But when the extract of Myristica fragrans with PTZ was injected to the animal, it reduced the operation of PTZ. In fact, the maximum dose of extract (600 μg per rat) could show variation to the positive control group PTZ.
M. Dadelahi, G.H. Vaezi and K. Keramati, 2010. The Effect of Cerebral Ventricular Injection Extract of Myristica Fragrans on Fear Behavior in Male Adult Rats of Wistar. Research Journal of Biological Sciences, 5: 656-663.