Authors : Hemmati Ali Asghar, Arzi Ardeshir and Tamri Pari
Abstract: Several studies have shown that grape seed extract possess anti-inflammatory effect because of its components such as procyanidine. The purpose of this study was the investigation of the anti-inflammatory effect of grape seed extract on formalin-induced edema in rat paw. Hydroalcohlic extract of grape seed (Vitis vinifera) was prepared using maceration method. Albino rats weighting 180-200 g were divided in to 5 groups as intraperitoneal GSE receiving (200, 400 and 600 mg kg-1), positive control (indomethacin 5 mg kg-1 p.o.) and negative control (normal saline 5 mg kg-1 IP), 30 min following IP injection of GSE or indomethacin administration 0.1 mL of formalin (2.5% w/v) was injected in rat hind paw and the changes in rat's paw volume was assessed by plethysmometer for 3 h at intervals of 1 h. Grape seed extract (200, 400 and 600 mg kg-1, IP) exerted anti-inflammatory effect in a dose dependent manner. Hydroalcoholic seed extract in dose of 600 mg kg-1 was more effective against formalin-induced paw inflammation. However, this effect was less potent than indomethacin (5 mg kg-1) effect as positive control.
Hemmati Ali Asghar, Arzi Ardeshir and Tamri Pari, 2010. Anti Inflammatory Effect of Grape Seed (Vitis vinifera) Extract on Formalin-Induced Edema in Rat Paw. Research Journal of Biological Sciences, 5: 760-763.