Abstract: These days, one of the real problems that cause the prejudice economic in animal farms yearly is parasitic diseases. For that reason to prevent these problems, the use of antiparasitic drugs is necessary. Ivermectin is a broad spectrum antiparasitic agent and different dosage forms such as injection, oral and pour-on used. The aims of this study were evaluation of the efficacy of ivermectin pour-on administration against natural oesophagostomum radiatum nematode infections in cattle and also determine the prevalence rate of this parasite in Tabriz area. In this study in 120 heads of male and female hybrid cattle were carried out LPG (larves per g of feces) feces test. Willis method was applied for feces test and Stoll method was used for counting nematode larves (LPG). After confirm worm contamination and counting oesophagostomum radiatum nematode larves in feces, in infected animals, ivermectin (0.5 mg kg^-1) pour-on was administrated. Feces test was repeated in 1, 7, 21 and 28 days after treatment. Results showed that total prevalence of oesophagostomum radiatum nematode infections was 18.33% in cattle’s of Tabriz area. The effects of ivermectin pour-on on oesophagostomum radiatum nematode were 56.36, 70.75, 92.68 and 99.52% in 1, 7, 21 and 28 days, respectively. In conclusion because the effect of this drug against oesophagostomum radiatum nematode was >99% (p<0.05), so in cattle can use this drug in antiparasitic program. Of course, the effect of this drug on other nematodes and parasitic infections are needed to be more investigated.