Abstract: Sage tea Salvia officinalis L. extract was evaluated scientifically for its anti-motility-related diarrhoeal effect of mice in current study by using castor oil as laxative agent-induced diarrhoea model against loperamide as standard anti-motility-related diarrhoeal drug. Fifteen male mice were used and divided into three groups (5 animals group^-1) ^+vecontrol, ^-vecontrol (loperamide treatment) and sage tea treatment groups, respectively. The results reported a reduction in purging index (137.78), significantly decreasing of the latency period (0.90±0.10) and number of stools (1.24±0.19) of S. officinalis L. sage tea treatment group as compared to ^-vecontrol (loperamide) (153.85), (2.00±0.32) and (1.30±0.20) and ^+vecontrol groups (254.72), (5.40±0.81) and (2.12±0.10), respectively. Concludes from these findings that an inhibitory action of motility-related diarrhea effect of Salvia officinalis L. extract is evident from the experimental model like castor oil induced diarrhea may be attributed to therapeutic properties of this plant which contains pharmacologically active substances with anti-motility related diarrheal properties.