Authors : Ali Rezaie, Babak Lotfollahi, Daryoush Mohajeri, Ghafour Mousavi, Mehrdad Nazeri, Solmaz Zakhireh and Babak Mohammadi
Abstract: Acceleration in healing of surgical skin wounds, in order to reduction of post-operation consequences is most important. One of the most popular compounds used ever for skin care is lavender oil or Lavandula stoechas essential oil. The aim of this study was evaluate the healing effects of Lavandula stoechas extract in comparison with zinc oxide ointment on full thickness experimental open surgical skin wound healing in the rats. For this purpose, 75 female Wistar rats were randomly assigned in 5 groups of 15 animals each including: Control, treated by Eucerin as the placebo, treated by zinc oxide topical ointment and two remaining as test groups which received 10 and 20% Lavandula stoechas extracts. Under the general anesthesia and analgesia circumstances, a full thickness incisional open wound with 23 mm diameter was made on the skin of the back part of the rats. The healing process was studied macroscopically and microscopically at 0 (the day of surgery) 3, 7, 14, 21 and 28th days of experiment in all of the rats. The greatest degree of wound contraction was considered in Lavandula stoechas extract (10%) treated rats while this change was slighter in control group. In microscopic examination, the overall healing process of Lavandula stoechas extract (10%) treated rats was significantly better than the other experimental groups (p<0.05). The results obtained showed that Lavandula stoechas extract (10%) has more effective healing properties on full thickness open skin wounds compared to zinc oxide topical ointment.
Ali Rezaie, Babak Lotfollahi, Daryoush Mohajeri, Ghafour Mousavi, Mehrdad Nazeri, Solmaz Zakhireh and Babak Mohammadi, 2011. Geometric and Histopathologic Assessment of Lavender Extracts (Lavandula stoechas) on Healing of Experimental Skin Wounds and its Comparison with Zinc Oxide on Rats. Research Journal of Biological Sciences, 6: 585-589.